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57585

Molecular evaluation of Hepatocyte Growth Factor (HGF) as a potential Biomarker to detect Hepatocellular Carcinoma

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Last updated: 22 Jan 2023

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Abstract

This study was carried out to investigate the noninvasive expression level of hepatocyte growth factor (HGF) in hepatocellular carcinoma patients and its relationship with diagnostic parameters.To active this goal we used thirty six patient divide to fourteen with HCC, twelve patients with HCV and ten healthy control patient matched in age and sex were investigated. HGF level wasdetected by quantitative polymerase chain reaction (qRT-PCR). The median age of the patients was 51 years (rang 44-58 years); where males constituted the majority of the group (69.4%). The entire patient had cirrhotic history. None of the patients were pretreated with local therapies. The baseline noninvasive HGF level wassignificantly higher in patient HCC than in the HCV and control groups (p=0.028), whereas HGF level was alsohigher in HCV patient than healthy patient. Further the correlation between the level of HGF and all laboratory parameters was tested. We found that there is a good positive relationship between HGF levels and SGPT (ALT), SOGT (AST), Platelets count.Finally we compared the predicative accuracy of HGF and a conventional tumor marker AFP by ROC curve; we found that the sensitivity of HGF (85.7%) to predict the HCC is higher than AFP (73%), and also the specificity.Overall, these results suggest that HGF could serve as a useful tumor biomarker for prediction of HCC in comparing with, HCV, and healthy control results.

DOI

10.21608/rjab.2017.57585

Keywords

HCC, HGF, AFP, ROC curve, Egyptian patients

Authors

First Name

Amira

Last Name

Abdallah

MiddleName

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Affiliation

Molecular diagnostics and therapeutics department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

Email

amoo201121@yahoo.com

City

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Orcid

-

First Name

Moustafa

Last Name

Sakr

MiddleName

A.

Affiliation

Molecular diagnostics and therapeutics department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

Email

mostafa.sakr@gebri.usc.edu.eg

City

-

Orcid

-

First Name

Ahmed

Last Name

Sharawy

MiddleName

-

Affiliation

Clinical Pathology Department, National Liver Institute, Menofia University, Menofia, Egypt

Email

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City

-

Orcid

-

First Name

Hisham

Last Name

Ismail

MiddleName

A.

Affiliation

Molecular diagnostics and therapeutics department, Genetic Engineering and Biotechnology Research Institute (GEBRI), University of Sadat City, Sadat city, Egypt

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City

-

Orcid

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Volume

3

Article Issue

1

Related Issue

7686

Issue Date

2017-06-01

Receive Date

2019-11-08

Publish Date

2017-06-01

Page Start

1

Page End

10

Print ISSN

2356-9433

Online ISSN

2682-3470

Article File

RJAB_Volume 3_Issue 1_Pages 1-10.pdf

PDF . 559.6kB

Link

https://rjab.journals.ekb.eg/article_57585.html

Detail API

https://rjab.journals.ekb.eg/service?article_code=57585

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8

Type

Original Article

Type Code

890

Publication Type

Journal

Publication Title

Research Journal of Applied Biotechnology

Publication Link

https://rjab.journals.ekb.eg/

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Article

Created At

22 Jan 2023