Greenhouse experiments were carried out in the Gammsa district of Dakahlya Governorate over two seasons (2016/2017 and 2017/2018), to investigate the impact of three drip irrigation levels, (100 , 80 and 65% of soil field capacity (FC), donated as I₁, I₂ and I₃, respectively  and partial replacement of biofertilizers to mineral fertilizers, F₁ (100% RNPK), F₂ (75% RNPK +50% of mixture of biofertale + rhizobacterien) and F₃ (55% RNPK + 100% of mixture of biofertale + rhizobacterien), on cucumber yield and its components. The economic return was considered as well. The results revealed that both irrigation and fertilization treatments had a highly significant impact on cucumber plant yield and attributes. In both seasons, the I₂ and F₃ treatments produced the highest cucumber fruit yield and the majority of its components. In the first and second seasons, respectively, fruit yield increased by (21.87 and 22.29%) in the I₂-treatment compared to I₁, and by the comparable values (10.78 and 13.18%) in the F₃-treatment compared to F₁. In both seasons, the combination of I₂ and F₂ or F₃ produced the highest values of net revenue, net revenue per water unit, and economic efficiency numbers, moreover, the I3 treatment surpassed the I₁ treatment in terms of irrigation water productivity and water savings. In conclusion: Under greenhouse conditions using sandy soil, I₂ paired with F₂ or F₃ is the most effective treatment for obtaining an economical cucumber fruit production, economic return, and saving water and mineral fertilizers.