Field trials were conducted at El-Serw Agricultural Research Station (North Delta) during the 1997/98 and 1998/99 winter seasons to investigate the influence of nitrogen fertilizer levels and irrigation water deficit during some growth stages on wheat yield, water consumptive use, water use efficiency and to develop wheat crop coefficient values for the North Delta area. Wheat cultivar Sakha 69 was used in this study. A split-plot statistical design with four replication was used. Four irrigation treatments (I₁ = full irrigation, I₂ = no irrigation at tillering, I₃ = no irrigation at heading, and I₄ = no irrigation at flowering) in the main plot and three N-fertilizer levels (N₁ = 30, N₂ = 60, and N₃ = 90 kg N/fed) in the sub-plots were tested. Results indicated that there was a significant effect of the tested variables on wheat grain and straw yields. Average grain yields were 2.03, 1.59, 1.78 and 1.75 t/fed for the I₁, I₂, I₃, and I₄ irrigation treatments, respectively. Water consumptive use values varied between 27.3 cm for the I₂ N₁ treatment to 39.66 cm for the I₁ N₃ treatment. Also, water use efficiency value of 1.57 kg grain/m³ water consumed was obtained from the I₁ N₃ treatment. Average seasonal crop coefficient value of 0.78 was obtained for wheat crop grown at the North Delta area. Tillering stage of growth was the most sensitive stage for water deficit at El-Serw area.