A field experiment was implemented in 2017/2018 winter season in privet farm at Nabarouh city, El-Dakahlia Governorate under open field conditions (31°06′52.3″ N 31°17′43.8″E) to study ֹthe effect of biological and mineral fertilizers on the productivity and quality of potato (Solanum tuberosum L, cv. Spunta). The experimental design was split-plot design with three replicates. The main treatments were without bio-fertilizer(B₀) and with bio-fertilizer(B₁) while the sub-main treatment was mineral fertilization at rates of (control = without KP-mineral fertilizer(KP₀), 33%(KP₁), 66%(KP₂) and 100%(KP₃) of potassium and phosphorus fertilizer recommendation dose for potato. The obtained results were: Biological fertilization (B₁) gave the highest mean yield of fresh and dry weight, 15.72 and 2.86 ton.fed^-1, respectively compared with B₀. Whereas 100% PK-mineral fertilization (KP₃) gave the highest mean yield of fresh and dry weight which was 16.02 and 3.13 ton.fed^-1, respectively. In addition, the interaction treatment B₁KP₂ gave the highest mean yield of fresh and dry weight (17.15 and 3.43 ton.fed^-1). Also, KP₃ led to the highest percentage of N, P and K (%), they were 0.79, 0.276 and 1.89%, respectively. The interaction treatment of bio with 66% of mineral fertilizers (B₁KP₂) gave the highest significant increase of N, P and K% in potato tubers hence it may saving 34% of mineral fertilization. With regard to the quality parameters for potato, it was found that bio-fertilization (B₁) was the best treatment for the quality characteristics as well as 66% of the recommended fertilizers dose and there were insignificant differences between B₁KP₂ and B₁KP₃.