The current study was conducted in the Northern Nile Delta (Hammoul District) to evaluate the effect of irrigation with agricultural drainage and blended canal water on growth characteristics, yield and its components, and grain quality of three rice varieties during two successive seasons of 2020 and2021. The irrigation treatments were as follows: irrigation using the agricultural drainage water(I₁), irrigation using agricultural drainage water, alternate with blended water one by one(I₂), and irrigation using the blended canal water(I₃). Sakha104, Giza177, and Giza178 rice cultivars were used in this study. The results indicated that heading days, plant length (cm), panicle length (cm), number of panicle hill^-1, number of filled grains panicle^-1, 1000- grain weight (g), grain yield (t ha^-1), and harvest index were better with blended canal water than that with agricultural drainage water. The greatest yield of the Giza 178 variety was achieved with blended canal water, while its yield was reduced by 9.6% when irrigated with drainage water. The results showed that the mean grain yield of Sakha 104, Giza177, and Giza178 in the 1^st season were 9.64, 8.69, and 11.31 t ha^-1and in the 2^nd season they were 9.83, 8.66, and 9.88 ton ha^-1, respectively. Also, the results showed that the yield of  Giza178 which was irrigated by drainage water was close to that produced by Sakha 104 or more than that of Giza177, which was irrigated by the blended canal water.Therefore, Giza178 cultivar can be irrigated by drainage water, since it surpassed both the cultivars under this condition.