The effect of pomegranate seed or peel added as dry matter or extract on lipid parameters and oxidatative state of hypercholesterolemic rats was studied. Hypercholesterolemia was induced in rats by feeding high fat. High cholesterol diet for 10 weeks. Groups of those rats received diet containing either pomegranate dry seed or peel powder. Others received the methanolic extract of either the seeds or peels. The plasma total cholesterol, HDL-C, LDL-C. VLDL-C, Triglycerides, Lipid peroxides, SOD and catalase activities were followed before and after each dietary regimen. The results obtained showed a significant increase in each of plasma total cholesterol, LDL, VLDL, Triglyceride lipid peroxides in rats given the HF. HC diet. The plasma HDL, activity of each of SOD and catalase enzymes were decreased. Addition of pomegranate either the seed or the peel in the powder form or as extract corrected that pattern and most of these parameters returned back to near normal level. Analysis of the pomegranate extract by HPLC revealed the presence of compounds including phenolic acids. fiavonals, catachin, isofiavones and fiavanones. These findings were interpreted and the conclusion reached is that pomegranate seeds and peels can protect from hypercholesterolemia and in turn atherosclerosis. The methanolic extract contain an appreciable quantities of phenolic compounds that posses antioxidative power. The antioxidative power of the peels is much higher than the seeds since it contains more of these compounds with antioxidant effect.