Nanotechnology can put advents for increasing yields to support agricultural sector and decreasing environmental risks. Also, natural plant extracts can stimulate the performance of plants grown on salt affected soil. A little is known about the joint effects of external application of moringa extract plus foliar spraying with Nanoparticles on garlic plants grown on saline soil. So, a field research work was executed aiming at assessing the influence of the external applications of moringa extract [ with (30 ml L^-1) and without foliar spray, as main plots], copper oxide Nanoparticles (CuO NPs)  as sub plots at different rates i.e, 0.0, 1.0 and 2.0 ng L^-1 and magnetite iron oxide Nanoparticles (Fe₃O₄  NPs) as sub-sub plots at different rates i.e, 0.0, 2.0 and 4.0 ng L^-1 on the performance of garlic plants grown on saline soil at two periods (100 and 180 days from planting). The findings indicate that the garlic plants grown on saline soil with foliar application of moringa extract had the best performance compared to the corresponding garlic plants grown without external application of moringa extract. On the other hand, the plant improvement increased as the rate of NPs increased. Generally, the best performance was recorded when garlic plants were sprayed in combination with moringa extract (30 ml L^-1), CuO NPs (2.0 ng L^-1) and magnetite Fe₃O₄ NPs (4.0 ng L^-1) compared to other combined treatments. Generally, it can be concluded that studied substances acted to mitigate the influences of salinity stress of soil on garlic plants.