Two pot experiments were carried out in the experimental farm of Faculty of Agriculture- Mansoura University to investigate the best integrated mineral and organic fertilization system which will reflect on increasing grain and straw yield as well as nitrogen fertilizer use efficiency by wheat (Triticum aestivum, L). The used experimental design was split split plot design with three replicates, the main treatments were mineral nitrogen form which were: urea 46% N, ammonium nitrate (AN) 33.5% N, urea formaldehyde coated urea (UFCU) 37.2% N and urea coated rock phosphate (UCRPh) 37.2% N. Subplots represent mineral nitrogen fertilization level as 50 and 100 KgNFed^-1, and organic amendments forms were allocated in sub-sub plots. Results showed that slow release mineral nitrogen sources (UFCU and UCRPh) were better than soluble nitrogen sources (Urea and AN) in increasing grain and straw yield as well as nitrogen use efficiency, also increasing mineral nitrogen level from 50 to 100 KgNFed^-1 led to an increasing in grain and straw yields in both seasons. On the other hand, organic amendments forms resulted in increasing grain and straw yields, in addition to mineral nitrogen use efficiency, and chicken manure was better than farmyard manure, that's because of its high content of available nitrogen content. Finally, it could be concluded that application urea coated rock phosphate at 100 KgNFed^-1 and 10 m³/ fed chicken manure was the best integrated treatment in increasing wheat grain and straw yields, as well as nitrogen use efficiency, and this will help to solve the gap between wheat supplies and demands in a friendly way with the environment.