This study aimed to investigate the possibility of feeding broiler chicks on diets containing irradiated (0, 100 and 150 kGy) grape residue (GR) supplemented with or without enzyme mixture (kemzyme) and studying their response on growth performance, some blood parameters and carcass characteristics. Two hundred and ten one-day old Arbor acres chicks were distributed into 7 dietary treatments in 3 replicates of 10 birds each, after reared on starter diet for 2 weeks. Experimental diets were formulated using 15% of (GR) either irradiated or unirradiated with or without kemzyme in addition to the control. Chicks were led the experimental diets from 2-7 week of age, body weight, weight gain, feed intake and feed conversion were determined. Blood parameters, electrophoretic profile muscle proteins and carcass characteristics were determined at the end of feeding period. The results showed that chicks fed on control diet had the highest body weight, weight gain and feed intake followed by chicks fed on diet containing irradiated (GR) at 100 kGy with kemzyme. The other applied level of dietary raw or irradiated (GR) had no significant effects on carcass traits and blood constituents.