The effect of gamma radiation on four packaging films [polypropylene (pp), low-density polyethylene (LDPE), polyamide/polyethylene (PA/PE) and polyester/polyethylene (PET/PE)] at levels of 5, 10 and 30 kGy were studied. The effect was included mechanical properties, gas and water vapour permeability and overall migration components from plastic packaging materials into distilled water, 3% aqueous acetic acid and iso-octane was studied. The results showed that, there were significant differences (p>0.05) between mechanical properties of non-irradiated and the samples which were irradiated at levels 5, 10 and 30 kGy for all studied polymers. Irradiation at 30 kGy decreased the impact strenght and percent elongation. The most affected of mechanical property by irradiation at 30 kGy was percent elongation. Irradiation decreased the overall migration from PA/PE and PET/PE into distilled water and 3% acetic acid. While, the overall migration from PP and LDPE, as well as the overall migration from all the tested packaging materials into iso-octane were  increased. The results indicated that overall migration values from all the tested films into distilled water, 3% acetic acid and iso-octane were lower than the upper limit for migration (10 mg/dm²) set by the EU.