In the present work 40 female albino rats were divided into two main groups Prophylactic and Curative. Prophylactic was treated with ginseng for four weeks before and after the induction of diabetes, while curative was treated with ginseng only after the induction of diabetes, besides, non treated control, Ginseng control and Diabetic control (each group 8 rats). Two main experiments were carried out. The first experiment represented the effect of ginseng as prophylactic agent against hyperglycemia induced by streptozotocin (STZ). The second depended on the curative effect of these treatments on hyperglycemic rats. Antioxidant parameters that protect the cell against reactive oxygen species (ROS) were carried out. Activities of antioxidant enzymes catalase (CAT) were measured. In addition, levels of antioxidant biomolecules involving glutathione (GSH), L-Ascorbic acid (vitamin C). Also, lipid profile and lipid peroxidation malondialdehyde (MDA) were measured. Data revealed that Ginseng roots supplementation improved blood sugar levels in diabetic rats and protected rats from diabetic factors like streptozotocin in prophylactic female albino rats.