An experiment was carried out by using 30 male albino rats divided into five groups after an adaptation period (7 days). The negative control (6 rats) was fed on basal diet, while positive control was fed on a hypercholesterolemic diet. The three treated groups were fed on hypercholesterolemic diets supplemented with 8 % of each of Pulicaria incisa, Diplotaxis harra and Avicennia marina, respectively. The duration period of the experiment was nine weeks, at the end of which the body weight gain, liver, kidneys functions and lipid pattern were determined. It was found that the addition of P. incisa gave the highest significant decrease in total lipid, total cholesterol, and triglycerides. Other plants also significantly decrease all these parameters but at lower different degrees. HDL-cholesterol, LDL-cholesterol, VLDL-cholesterol, chylomicronae- mia, TG/LDL-cholesterol ratio, HDL-cholesterol/Pooled lipoprotein, atherogenic index and ratio of HDL-cholesterol/LDL-cholesterol were   also determined in rat's serum. Most organs functions were improved and approached nearly the negative control levels of  S.G.O.T., S.G.P.T., S.G.O.T./S.G.P.T. ratio, s. albumin, s. total protein, s. globulin, s. total bilirubin, albumin/globulin ratio, s. uric acid and blood urea. Also, s. glucose was nearly returned the negative control group.