A field experiment was conducted over two successive seasons (2006/2007 and 2007/2008) at Borg El-Arab area, on North western of Egypt and about 65 km from Alexandria city, to study the effect of phosphorus, sulphur and zinc applications on P and Zn uptake, growth, yield and its components of wheat plant (Triticum aestivum L.) CV. Sakha 69. Phosphorus rates were 0, 60 and 120 kg P₂O₅ ha^-1, as superphosphate, and zinc application rates were 0, 5 and 10 kg ZnO ha^-1 as (ZnSO₄.7H₂O) either without or with one sulphur application rate (100 kg S ha^-1). The used soil type was Aridisols (Calciorthids); calcareous sandy clay loam soil. The results obtained showed that plant height and dry weight/plot were responded to P and Zn treatments and this response was significantly increased in the presence of sulphur application. The P uptake by roots was significantly increased with increasing P rates, when combined with added Zn without of S application, at the booting (ZGS 31) and soft dough stages (ZGS 45). On the other hand, in the presence of S, there were insignificant increase of P uptake by roots and significant increase of P uptake by shoots with increasing of P rates when combined with increasing of Zn rates as compared with the control. The Zn uptake was significantly increased in roots and significantly decreased in the shoots with increasing of P and Zn rates without S application as compared to the control. Whereas, plots that treated with S gave the highest shoot Zn uptake. Increasing P and Zn rates significantly increased grains P and Zn uptake and the highest uptake values were obtained in plots that treated with P, Zn and S. The application of P and Zn without S did not significantly increase the yield and its components as compared with the control. The highest values of yield and its components were obtained at the highest rates of P and Zn that combined with 100 kg S ha^-1, and those values were 548, 794, 3.38, 4.72, 15.88, 20.60, 22.91 and 13.28 for number of spikes/m², weight of spikes (g/m²), grain index (g), grain yield (ton ha^-1), straw yield (ton ha^-1), biological yield (ton ha^-1), harvest index (%) and protein percentage, respectively.