To evaluate effects of NPK and potassium humate application under two tillage systems, i.e., no tillage (direct sowing) and full tillage, on soybean productivity, field experiment was conducted in successive seasons of 2019 and 2020. The experimental design used was a split-split, with four replications. Results indicated that tillage system had no effect on soybean productivity, except nodulation parameters, where no-tillage system gave the highest number of nodules plant^-1 and dry weight of nodules plant than full tillage. Fertilization with NPK enhanced all studied growth parameters, i.e., plant height, nodulation, yield components (number of pods plant^-1, number of seeds pod^-1 and 100-seed weight), yield measurements (seed and straw yields), N, P and K concentrations in seeds and straw as well as seed quality (protein and oil percentages and yields) when compared with control. Phosphorus had more pronounced effect than the other two nutrients. Also, application of 24 kg potassium humate as soil application improved all the above-mentioned quality and quantity of soybean plants. Moreover, no tillage and potassium humate application improved soil reaction, organic matter, bulk density, soil available water and wilting point after soybean harvesting. From these results, it could be concluded that cultivating soybean plants without no tillage, fertilizing with 72, 33 and 95 kg N, P and K ha^-1 and 24 kg potassium humate ha^-1 as soil application is recommended in order to maximize soybean productivity, meanwhile minimize its costs.