Grapevine fertilization is one of the most sensitive practices, particularly interested in management package. Three years study (2004, 2005 & 2006) has been conducted in a private vineyard located at El-Khatatba region, Menofia Governorate to investigate the effect of ureaform (UF) as a slow release nitrogen fertilizer and ammonium nitrate (AN) as an ordinary one with or without application of farmyard manure (FYM) on yield and quality parameters of Thompson seedless grapes (Vitis Vinifera L.). Results indicate that no significant effects for the different treatments on the morphological characters have been observed except that of leaf area which has shown clear response to both UF treatment rates and FYM application. Also, it is observed that such character values were superior in the 3^rd year to those of 2^nd one. All treatments have given good quality grape yield. However, it is observed some inferiority concerning total sugar and total soluble solids as well as high acidity in condition of available nitrogen glut expected and due to high nitrogen rates or FYM application. In 2^nd year, it is observed positive effect for each FYM and UF treatment on cluster weight, yield/ vine and yield/ fed. The UF rate of 96 kg N/fed without FYM and 48 kg N/ fed with adding FYM have been the most superior. In the 3^rd year, No effective for FYM application on the yield or their components has been marked, yet on the contrary, the nitrogen treatments without FYM application have given the most yield, it is also observed that the treatments tagged (+) have given yield more than those tagged (*) regardless fertilizer type or rate. Concerning the economic evaluation, net return and investment factor (IF) of UF treatments  has been superior to those of AN treatment in case of no adding FYM, the contrary has been true in case of FYM application. In the 2^nd year, it is illustrated that the optimum rates to fulfill the maximum profitability have been 96 kg N/ fed. without FYM application and 48 kg N/ fed. with FYM application. In the 3^rd  year, and because of its yield has been more than that of 2^nd  one, its net return has been so much comparing with those of 2^nd  one. Generally, the treatments have not received N-fertilizer in the 3^rd year has been the most profitability although its net return has been less than those received N-fertilizer. This means that the highest yield does not mean the highest profitability. However, still the rate 96 kg N/ fed. without FYM application and 48 kg N/ fed. with FYM application have been the most profitability.