Two field experiments were conducted at a private farm on Gadila Village, Mansoura City , Dakahlia Governorate  , Egypt under alluvial soils of Nile delta, during 2017 and 2018 summer growing seasons as sake of studying the effect of potassium humate (KH) sprayed singly or in dual,triple and quadruple combinations (9 mixtures) with some micronutrients(Fe , Mn and Zn )on leaves photosynthetic pigments ; yield and yield attributes as well as nutritive and biochemical contents of sesame seeds. KH and micronutrients were sprayed; once , at 21 days after sowing (DAS) ; twice, at 21 and 35 DAS and triple, at 21 , 35 and 50 DAS. So ,a split plot arrangement with three replications was used , where number of foliar spraying times for both KH and micronutrients were allocated in the main plots however , nine treatments of different combinations of KH and micronutrients were randomly distributed in the sub – plots . The highest values for all traits mentioned before were attained upon foliar spraying of sesame plants, triple compared to those sprayed twice and once, respectively. Spraying KH and micronutrients simultaneously in a quadruple combination i.e.( KH + Fe + Zn + Mn )also gave the best values  followed by their additions in triple ,dual combinations however,  spraying of KH alone achieved the least values . Therefore , spraying sesame plants with( KH + Fe +Zn +Mn )three times achieved the highest increments for all criteria under investigation related to the quantity and quality of sesame .