Egypt is one of the countries that produce the best Hibiscus(karkadeh)in world, especially in Upper Egypt. Determine the fertilization and irrigation requirements consider of the most important agricultural practices for roselle plant as a medicinal plant.A field experiment was carried out during the two successive summer growing seasons 2017 and 2018 at Kom Ombo Agriculture Research Station,Aswan Governorate, Egypt (24° 28^' 38.604" N and 32° 56' 50.671" E),to evaluate the response of roselle plant to NPK fertilizers rates, compost as organic fertilizer and irrigation at different intervals. Treatments were carried out as Split Split Plot Design with three replicates; the main plots were three irrigation intervals(every 3, 6 and 9 days);the split plots were organic fertilizer, Org₀(without)and Org₁(4 m³ fed^-1 compost "Hundz soil compost"),and the sub split plots were 3 rates of NPK fertilizers(100; 75 and 50 % of recommended NPK).Results showed thatgrowth of roselle plant significantly responded to fertilization at 100% NPK, compost and irrigation every 3 days,where fruits number and weight and sepals yield showed adverse response. They were superior with fertilization at 75 and 50 % NPK,compost and irrigation every 6 days.Sepal's content of nitrogen,anthocyanin and cyaniding significantly were affected by the interaction of NPK-fertilizers rates with compost and irrigation intervals, and also the plant uptake of NPK. Results concluded maximize yield of roselle plant grown in Aswan Governorate fertilized plants with 56.25 kg N, 22.5 kg P₂O₅ & 27 kg K₂O per fed(75% of RD NPK),along with compost application and irrigation every 6 days.