A field experiment was conducted during two winter seasons 2018/2019 and 2019/2020 at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, Egypt to study the effect of deficit irrigation and weed control treatments on grain yield and water productivity of three bread wheat genotypes. The experimental design was stripe split-plot, with three replicates. Irrigation treatments were in the vertical plots which include I₁ irrigation at all stages (full irrigation), while I₂, I₃ and I₄ were deficit irrigation through withholding one irrigation at elongation, booting, and anthesis stages, respectively. Four weed control treatments were allocated in horizontal plots that include, W₁ (Gerostar + Action), W₂ (Atlants), W₃ (hand weeding twice), and W₄ control (untreated), Sub-Subplots were three wheat genotypes G₁ (Giza 171), G₂ (Sakha 95) and G₃ (promising Line).  The results revealed that the highest values of plant height, number of spikes m², number of kernels spikes^-1, 1000-kernel weight, biological yield, grain yield and straw yield were recorded under I₁ compared to all the studied irrigation treatments, as well as under W₁ compared to other weed control treatments and G₂ compared to others genotypes in the two seasons. The highest values of water consumptive use (CU), and applied water (AW) were recorded under I₁ to be 37.67, and 48.26 cm respectively, the values of AW under I₂, I₃ and I₄ were reduced by 18.5%, 17.6%, and 22.3% respectively compared to I₁ as mean of the two seasons. The values of productivity of irrigation water (PIW), and water productivity (WP) were taken the descending order W₁> W₂ > W₃ > W₄ and G₂ > G₁ > G₃ for weed, and genotypes respectively. It could be recommended the I₂ × W₁ × G₂ interaction which recorded the highest grain yield, PIW and WP, moreover saved a reasonable amount of irrigation water.