Two field experiments were conducted during winter seasons of 2018/2019 and 2019/2020 at Sahl El-Hussainia Agric. Rcs. Station, El-Shakia governorate, to study the effect of addition of soil conditioners (compost, gypsum and bio-fertilizer alone or combination on some soil chemical and physical properties of saline soil and yield, yield components and chemical composition of wheat plant (Triticum astivum L.). The results showed that all used amendments either solely or combined application led to decrease EC (dSm^-1), pH, SAR and ESP compared with control. The Bulk density, porosity and infiltration rate were positively affected by soil amendments.  The combined application of compost and gypsum or between compost and bio-fertilizer were more affective than single one the soil chemical and physical properties. All treatments were significantly increase wheat yield and yield components. The highest significant effect on wheat yield and yield component were obtained by application compost+ gypsum, and also N, P, K, Zn, Fe, Mn in grain and straw.