There is a severe shortage in irrigation water supply in North Delta area, especially Kafr El-Sheikh Governorate, Egypt. The shortage in fresh water supply in farmlands located on the tail end of irrigation canals has to be replenished by the available drainage water. So, the current work focused on assessing water quality of El-Hoks Drain for irrigation with respect to its contents of ammonium- N (NH₄-N), nitrate-N (NO₃-N), salts, dissolved oxygen (DO), biological oxygen demand (BOD), chemical oxygen demand (COD), boron (B) and some heavy metals. Sixty water samples were collected from ten branch drains' discharge in El-Hoks Drain during winter (2017/018) and summer (2018) seasons. According to FAO (1985) and Egyptian standards (Law 48/1982), results showed that BOD, COD and NO₃-N are the main pollutants, which BOD and COD values are classified between bad to slight and moderate, whereas, NH₄-N and NO₃-N values fall within the normal range for irrigation, but it is in the abnormal range based on the Egyptian standards. DO Values are in the normal range for irrigation according to Egyptian standards. Also, values of heavy metals Cu, Mn, Pb and Cd exceed the allowable limits for irrigation except Ni which falls within the normal range. B values in water samples fall between bad and good. Meanwhile, pH values ranged from 7.37 to 7.95, EC values ranged from 1.16 to 2.71 dSm^-1, while SAR values varied from 5.74 to 8.64 which are suitable for irrigation and their values were higher in winter than in summer.