Two field experiments were held in a private farm at El-Mansoura District, Dakahlia Governorate, Egypt during the 2015/2016 and 2016/2017 seasons to study the effect of bio-, organic and mineral fertilizers on the growth and chemical composition of wheat plant, Sids 12 cultivar. The experiments were carried out in a split plot design with four replicates. The main plots were assigned to organic and bio-fertilizers (control= B₀O₀, organic only= B₀O₁, Bio only= B₁O₀, bio+organic= B₁O₁). While the sub plots were allocated to five levels of mineral fertilization (0-25-50-75-100% of the recommended fertilizers of NPK doses for wheat plant). The results showed that grain yield productivity as a result of adding the organic + biological treatment (B₁O₁) + without adding mineral fertilizers, was almost identical to that treated with 50% of mineral fertilization without biological and organic fertilization in both seasons. While straw yield obtained due to adding biological +organic treatment (B₁O₁) + without adding mineral fertilizers, was almost matched with 75% of mineral fertilization without biological and organic fertilization (B₀O₀) in both seasons. Also, the distinction of treating organic fertilizer only appeared in comparison to the biological only, while the effect of overlap between them was the largest under all levels of mineral fertilization concerning for all characteristics of the study. From the results of this study, mineral fertilization at the level of 100% with the addition of biological and organic fertilizers can be recommended to wheat plant under the conditions of Dakahlia Governorate, Egypt.