The aim of this study is to assess the extent of heavy metals contamination in soil and plants grown thereon (i.e., bean. clover, cotton and swiss chard) due to irrigation with different qualities of water. Therefore, soil, water and plant samples were taken from the investigated area, which located Eastern the Nile Delta, South Manzala lake and West canal of Suez. Soils of this area are, generally, irrigated with mixed water from El-Salam canal except for a small area that is irrigated with wastewater from Bahr El-Bakar drain. Results obtained showed that total concentrations of Zn, Cu, Ni, Pb, Cd. As and Se in the mixed water of El-Salam canal and wastewater of Bahr El Bakar drain were greatly less than the maximum levels allowed for irrigation .The sequence of irrigation water sources according to their contamination with heavy metals was El-Salam canal-2 water (1 El-Salam canal -1: 1 drainage water)> El-Salam canal-1 (7 Nile water: 1 drainage water) > Bahr El-Bakar drain water. Total concentrations of Zn, Cu, Pb, Cd, Ni and Se in the surface layer of studied soils ranged from 73.9 to 80.4, 50.8 to 55.1, 26.5 to 41.1, 0.66 to 1.5, 53.8 to 60.8 and 2.23 to 6.0 mg kg^-1, respectively; whereas As was not found in a detectable concentration. Also, concentrations of the DTPA-extractable Zn, Cu, Pb, Cd and Se ranged from 0.82 to 1.25, 3.6 to 5.85, 0.53 to 0.82, 0.006 to 0.015 and 0. 043 to 0.12 mg kg^-1 soil, respectively. Whereas Ni and As were not found in detectable concentrations. Total accumulations of the concerned heavy metals in the soils were less than the maximum permissible loadings according to USEPA-503 regulations. Total content of Zn, Cu, Se, Pb and As in shoots and roots of the grown plants were, to a great extent, in the normal range. However total content of both Cd and Ni were slightly higher. Generally, the sequence of heavy metals in the studied plant shoots and roots according to their concentrations was as follows: Zn≥ Cu> Ni> Pb> Se> Cd>As. Total concentrations of Zn, Cu, and Ni in all plant shoots were mostly higher than in roots; whereas concentrations of As and Se in both shoots and roots were, more or less, the same. On the other hand, total contents of Pb and Cd in the roots were higher than in shoots.