Two field experiments were performed at Village No. 1, west of Samallote, Minia Governorate, Egypt during 2004/2005 and 2005/2006 seasons to study the effect of four levels of farmyard manure (0, 10, 20 and 30 ton/fed); NPK fertilization doses, (i.e. 0, low (60/15/24) and high (120/30/48) kg of N, P₂O₅ and K₂O/fed) and the micronutrients (Fe, Mn, Zn and Cu) which were applied, soil application or as foliar spraying on N, P, K, Fe, Mn, Zn and Cu uptake by wheat plants (Sids 1 cv) grown on a sandy soil and their availability in soil. The results could be summarized as follows; Uptake of N, P, K, Fe, Mn, Zn and Cu by wheat plants significantly increased with increasing rate of the applied FYM and NPK, as well as the micronutrients application, where foliar spraying surpassed soil application in both seasons. The soil availability of N, P and K responded to manuring only. However, phosphorus only significantly increased by increasing NPK fertilization. Soil available contents of Fe, Mn, Zn and Cu were significantly affected by manuring and micronutrients as soil application, while foliar spray did not affect contents of these micronutrient in both seasons. It could be concluded that wheat under sand soils should be fertilized with 30 ton FYM/fed; NPK at rate of 120 kg N, 30 kg P₂O₅ and 48 kg K₂O/fed. Also, the micronutrients should be applied to improve both nutrients uptake by wheat plants and their availability in soil.