Two field experiments were performed in Village No. 1, West of Samallote, Minia Governorate, Egypt during 2004/2005 and 2005/2006 seasons to study the effect of four levels of farmyard manure, i.e. 0, 10, 20 and 30 metric ton/fed; NPK fertilization doses i.e. (0/0/0), (60/15/24) and (120/30/48) (kg N/P₂O₅/K₂O/fed.) and methods of Fe, Mn, Zn and Cu micronutrient application, namely without micronutrients, soil application and foliar spraying on dry weight, grain and straw yields and nutrient use efficiency of wheat Triticum aestivium, (cv Sids 1) under a newly cultivated sand soil conditions. Dry weight and grains and straw yields showed positive response to application of 30 ton FYM/fed, the use efficiency for N, P and K decreased with increasing organic manure potentially at the highest FYM rate. Dry weight and grain and straw yields as well as NPK-use efficiency increased as NPK increased to the highest level. The lowest values in P- and K-use efficiency were recorded with the low NPK rate. Application of micronutrients increased grain and straw yields as well as N, P and K use efficiency. Foliar spray surpassed soil application on grains and straw yields, but soil application method exerted the highest values of N, P and K use efficiency. Results recommended that wheat under sand soils should be fertilized with 30 ton FYM/Fed, NPK at rate of 120 kg N, 30 kg P₂O₅ and 48 kg K₂O/fed and micronutrients (Fe, Mn, Zn and Cu) as foliar spraying.