Two field experiments were conducted at Sahl El-Tina at North Sinai Governorate in private farm in two successive summer seasons of 2009 -2010. The study was conducted to check up the effect of applying gypsum, sulphur and compost on availability of nutrients in soil and sesame productivity grown under saline soil condition. The seeds of sesame were Cv. (Shandawil 3). Application rates for gypsum and compost were 0, 2 and 4 Mg fed^-1  but it was 0, 0.2 and 0.4 Mg fed^-1 for sulphur. Addition was performed 30 days before sowing . Basial fertilizers were applied at the recommended doses ; and were applied in 3 successive doses. The results showed that the application of high rate of all amendments led to decrease EC and soil pH. Available macro and micronutrients in soil were elevated with increasing the rate of application of gypsum, compost and sulphur.  Compost treatment at 4 Mg fed^-1 gave the highest seed yield and oil contents of sesame; compared to the zero level of amendments. Elevating the application rates of the studied treatments heightened the uptake of macro and micronutrients in the seed of sesame. Again compost treatment superimposed the other studied treatments. Consequently,it may be recommended to utilize 4Mg fed^-1 of compost to have good and higher quality of sesame  yield grown on salt affected soil.