A water culture experiment was conducted in summer season 2009 to evaluate the effect of increasing cadmium concentrations; (0.0, 0.5, 1.0 and 1.5 mg l^-1) on growth and some nutrients content of tow species of lettuce plant (Lettuce (lactuca sativa) and Crisp Lettuce (lactuca Sativa Varity Crispa)). The results could be summarized as follows: 1-The dry matter yield (shoots and roots) of the tow Varieties were decreased by increasing cadmium concentration. 2-Cadmuim uptake by plant was increased by increasing concentration in growth media. 3-Concentration of cadmium in roots was higher than the concentration of shoots for tow species. 4- Excluding Fe content, the Zn, Mn, Cu, P and K decrease with increasing cadmium concentration of plant shoots. 5- Excluding K content, the Zn, Fe, Mn, Cu and P increase with increasing cadmium concentration of plant shoots as compared with the control. 6- The Lettuce (lactuca varity) at the low concentration was higher tolerant more than the Crisp Lettuce Varity; while at the highest concentration the Crisp Lettuce Varity was better in tolerant than the Lettuce Varity.