A field experiment was implemented in 2015/2016 winter season at the Experimental Farm, Faculty of Agriculture, Mansoura University, Mansoura, Egypt, to study the effect of organic, biological and mineral fertilizers on the productivity and quality of potato plant. The experimental design was split-plot design with four replicates. The main treatment (control=without organic and bio(O₀B₀)- Organic fertilizer(O₁B₀)- bio-fertilizer(O₀B₁)- organic fertilizer+bio-fertilizer(O₁B₁) while the sub-main treatment was mineral fertilization at rates of (100%,75% and 50%of fertilizer recommendation dose). The obtained results were: Biological and organic fertilization (B₁O₁)+75% of mineral fertilization resulted in a significant increase in the yields of fresh and dry weight, 17100  and 3099.38 kg.fed^-1, respectively. Also, (B₁O₁) led to a significant increase in the (%) of N,P and K in potato tubers, where it gave the highest content of nutrients 1.03, 0.4788 and 2.3%, respectively. While 100% of NPK fertilizers led to a significant increase in the N,P and K percentage(%), they were 0.92, 0.3667 and 1.97%, respectively. There were insignificant differences between the means of B₁O₁+75% and B₁O₁+100%. Therefore, the treatment of  bio+ organic fertilizers with 75% of mineral fertilizers may be simulated with the treatment of 100% of mineral fertilizers, it means that may be saving in mineral fertilization by 25%. With regard to the quality parameters for potato, it was found that for total soluble solids (TSS), protein%, starch%, and %dry matter, the effect of treatment of organic+bio-fertilization (B₁O₁) together was the best treatment for the quality characteristics as well as 100% of the recommended fertilizers dose.