Two field experiments were conducted at the Experimental farm of Sids Agriculture Research Station, ARC, Beni-Suef Governorate  to investigate the possibility of reducing the recommended rate of mineral nitrogen (NRR) and phosphorus (PRR) fertilizers by using monoammonium phosphate (MAP) as 1% foliar spraying twice or biofertilizer and its effect on quality and quantity of cotton (Gossypium barbadense, Giza 95 variety). The results show that increasing nitrogen, phosphorus and added bio-fertilizer were significantly increased growth parameters, except first fruiting node, yield and yield components and seed index of cotton, while lint percentage decreased. On the other hand, earliness percentage was negatively responded to nitrogen levels and positively to phosphorus and bio-fertilizer. The studied treatments were not affected fiber properties. Combined 75% NRR+1% foliar spraying of MAP twice or using bio-fertilizer gave similar effect on quality and quantity of cotton, equal to that under 100 % NRR and100 %PRR, which means the possibility to save about 25 % from recommended rate of nitrogen and phosphorus by foliar spraying of phosphorus or bio-fertilizer.