The effect of using some foliar spray stimulating agents (amino acids, potassium humate, micro-nutrients), as a spray application with humic acid and mineral fertilizers on yield and quality of Cassava plants (Indonesian, cv.) was studied.  Moreover, the need for installation of drainage system was also investigated to maintain both soil salinity and water table in safe limits for plants. A field experiment was carried out at Al-Kassaseen Research Station – Ismailia Governorate, Egypt. The experiment was conducted during the two summer seasons 2017 and 2018. Mineral fertilizer was used as a recommended dose with or without humic acid and with or without foliar spray stimulating agents (amino acids, potassium humate, micro-nutrients).The experiment included eight treatments. The obtained results indicated that the maximum productivity of Cassava tubers was observed with mineral fertilizer with humic acid and stimulating agents compared to control. Total yield of tuber fresh weights and dry matter % of Cassava had the following decreasing order:MHP > MHA> MHN >MP >MH> MN > MA > M. Moreover, a pronounced increase in tubers quality with (dry matter, starch, total sugar, crud protein and vitamin C) and nutrient contents (N, K, P, Zn, Mn, Fe and Cu) of Cassava tubers was noticed with the application of foliar stimulating agents under mineral fertilizer with humic acid compared to control.The results showed also a decrease in soil salinity compared with the control (M) for different treatments of the study after harvesting Cassava according to the following order :MH > MHA or MHP > MHN >MP >MA >MN. The recommended calculated drain spacing in this area according to measured field data is 100 m spacing between drains and the recommended drain depth is 1.2 m.