In a field trail at Wadi Sudr Research Station (Desert Research Centre) South Sinai in season (2006-2007), the effect of nitrogen, potassium and sulfur on wheat yield, nutrients content and uptake. Three levels of N: 60, 90 and 120 kg/fed, five levels of K: 0, 50 and 100 kg K₂O/fed were added to soil in one dose totally with the first nitrogen dose and the same rates 50, 100 kg K₂O/fed  but were divided into two equal doses (25+25), (50+50) and were added to soil at the same time of adding N fertilizer and two concentration, (1.5% and 3%) of K₂SO₄ (50% K₂O) as a foliar application and two levels of S: zero (without) and one ton/fed. The results revealed that the yield of wheat, mineral content, and uptake were significantly increased as affected by NKS fertilization. Combination of N, K and S proved most effective with optimum yield of treatment 90 N, 100 K₂O and with sulfur (one ton/fed).