Two field experiments (tomato and squash)  in rotation were conducted at Sakha Agricultural Research Station Farm, Kafr El-Sheikh Governorate, Egypt during the summer and the autumn seasons of 2008 and 2009 to evaluate the effects of some multinutrient fertilizers for long term cultivation under two irrigation systems on crop yield and soil quality. The experiments were carried out under wire proof green house conditions. Tomato (Lycopersicon esculentum L) seedlings under the local name of Alessa was planted . Two irrigation systems and nine fertilizer treatments were examined . Split plot design was used with four replicates. The main plots were assigned by two irrigation systems (surface furrow irrigation, and drip irrigation). The sub plots were randomly assigned by nine fertilizer treatments of :- 1-control (without fertilization), 2- recommended dose of N and P (200 kg N and 13.08 kg P fed^-1), 3- recommended dose of P and K (13.08 kg P and 41.5 kg K fed^.-1), 4- recommended dose of N and K, 5- multinutrients 20 – 20 – 20 +1% Mg + micro nutrients, 6- multinutrient 20 – 20 – 20 + 1% Mg, 7- multinutrient 20 – 20 – 20 NPK as compound fertilizer (200 kg fed^.-1), 8- commercial multinutrient 20 – 20 – 20 NPK as mixed fertilizer and 9- recommended dose of N. P and K (as urea, superphosphat and potassium sulphate). Squash was transplanted on the same design without fertilization depending on the previous fertilizer residuals. The obtained results can be summarized as :- surface irrigation gave higher tomato fruit yield of 32178.3 kg fed^-1, the highest dry fruit weight of 2413.37 kg fed^-1,  higher P %, P content of the fruits (0.257% and6.2 kg fed^-1) respectively, higher values of K % in the shoot and fruits
( 0.9 and 2.7%) , NUE, PUE, KUE and the highest squash fruit yield of 10202.67 kg fed^-1. Drip irrigation produced the highest N % in the shoot and fruits of 0.602 and 0.912 % respectively. Surface irrigation generally decreased available N, K in the soil after squash while available P was increased compared to the values before planting. The highest tomato fruit yield of 31105.2 kg fed^-1, N% in tomato shoot of 0.677%, NUE155.5, PUE 814.0 and KUE 622.1 were obtained with T5. The highest K uptake 134.38, NUR% 27.42, PUR% 27.63 and KUR% 195.50 were obtained with T9.