A pot experiment was carried out in the green house of Soils and Water Department, Faculty of Agriculture, Al-AzharUniversity, during the winter of season (2009).  The current work was carried out to study the effect of irrigation water salinity, farmyard manure levels and moisture content on the yield and nitrogen (content and uptake) of wheat grains of   wheat plant grown on a calcareous soil. Wheat plant (Triticum aestivum, L.) Sakha93Variety, used as an indicator plant to experiment treatments. Four salinity levels of irrigation water were prepared (0.43  (Control), 1.56, 3.12 and 6.25 dSm^-1) under different moisture contents (100%, 75% and 60%) of field capacity determined by weight and four organic matter levels (0% (control), 1%, 2% and 4%) farmyard manure(FYM). Twenty grains were sown in each pot and the treatments were three replicates including control. After 15 days, the pots were thinned to 10 seed lings. The obtained results showed that yield of both grains and straw, and nitrogen (content and uptake) in grains were significantly decreased with increasing salinity levels. Increasing of farmyard manure application rates up to 2% increased significantly yield of both grains and straw, and nitrogen (content and uptake) of grains. Yield of both grains and straw and nitrogen (content and uptake) of grains were significantly increased with increasing moisture levels regardless effect of salinity and farmyard manure.