The present investigation was conducted at Hawaret El-Maktaa village, El- Fayoum District, Fayoum governorate, Egypt, during 2010 and 2011 seasons to study the combined effect of sowing dates i.e. S₁: May 2^nd, S₂: May 16^th and S₃: May 31^st and scheduling irrigation treatments, i.e. irrigation at I₁: 0.7 cumulative pan evaporation (C.P.E.), I₂: 0.9 and I₃:1.1 C.P.E. on seed yield, yield components, seed oil content and some water relations of sesame crop (Shandaweel -3 cv.).The split-plot design with four replications was applied, where sowing dates were allocated to the main plots and the split ones were occupied with irrigation scheduling treatments. The main obtained results were as follows:-   Highly significant increases in plant height(179.22 180.50 cm), capsule number/plant (156.42, 165.70), seed weight/plant (19.88, 20.21 g) and seed yield (612.80,  605.89 kg fed^-1) in 2010 and 2011 seasons, respectively, resulted from planting on 2^nd May and irrigation at 1.1 C.P.E. interaction. The increases in1000-seed weight were not significant in the two seasons, while seed oil content % exhibited similar trend in the first season only.   Seasonal consumptive use (ET_C) averaged 51.05 and 49.83 cm in 2010 and 2011 seasons, respectively. Planting sesame on May  2^nd and irrigation at 1.1 C.P.E. gave the highest ET_C values i.e. 55.35 and 54.46 cm in the two successive seasons. Nevertheless, the lowest ET_C values i.e. 47.37 and 45.72 cm were detected from planting on May 31^st and irrigation at 0.7 C.P.E. in both seasons, respectively. The crop coefficient (K_C) average, under interaction of 1^st sowing date and irrigation at 1.1 C.P.E., were 0.45, 0.55, 0.85 and 0.64 for May, June, July and August, respectively.    The highest water use efficiency values i.e. 0.264 and 0.265 kg seedsm^-3 consumed water were obtained from planting on May 2^nd and irrigation at 1.1 C.P.E. interaction in 2010 and 2011 seasons, respectively. However, it is advisable to irrigate the early planted sesame crop according to 0.9 CPE treatment to obtain acceptable figure for water use efficiency and to save irrigation water as well.