Two pot experiments were conducted at Soil Improvement and Conservation Research Dep. at Sakha Agricultural Research Station, Kafr El-Sheikh Governorate, North Nile Delta, Egypt during winter season 2018/2019. The factorial experiments were carried out in a complete randomized block design (CRBD) to study the effect of peat moss, compost, vermiculite, compost+ peat moss (1:1), peat moss + vermiculite (1:1), compost + vermiculite (1:1) and compost+ peat moss+ vermiculite (1:1:1) on growth, productivity and quality of lettuce (cv .Beqbal) and red cabbage (cv.Naden). The obtained results showed clear variation in the chemical and physical properties of different media after plants harvesting. The chlorophyll content, plant height and head diameter of lettuce and red cabbage values were significantly affected by different growth media. The highest values of these parameters were obtained by the mixture of compost+ peat moss+ vermiculite, while the lowest values were observed in plants grown in vermiculite. On the other hands, the mixture between compost+ peat moss+ vermiculite increased the valid, fresh and dry weights/plant of lettuce by 330.4, 336.8 and 109.8%, respectively, while the corresponding increases of these parameters in red cabbage were 216.4, 173.1 and 43.0%, respectively comparing to vermiculite. Also, this mixture achieved the highest values of NPK percentage for lettuce and red cabbage. In contrast, the lowest values of NPK were recorded with vermiculite media.