A Field experiment was conducted during 2011 - 2012 cultivation season at Sakha Agricultural Research Station Farm, Kafr El-Sheikh Governorate to evaluate the effect of some irrigation systems (surface irrigation "I₁", semiportable sprinkler "I₂", minisprinkler "I₃", floppy sprinkler "I₄", surface drip "I₅" and sub-surface drip "I₆" and N application methods (100 % fertigation "N₁", 75 % fertigation + 25% soil application "N₂", 50 % fertigation + 50% soil application  "N₃", 25 % fertigation + 75% soil application "N₄"  and 100 % soil application "N₅") on wheat (var. Sakha 93) yield, N uptake, N use efficiency and soil available N remained after harvesting. The main results could be summarized as follows:   1- Surface irrigation system (I₁) and N₁ treatment achieved the highest values of wheat grain and straw yields, while the lowest values were recorded with subsurface drip irrigation system and N₄ treatment. 2- I₁ and N₂ treatment gave the highest 1000 kernel weight, while I₆ and N₄ treatment gave the lowest value. 3- The highest values of N uptake, and N use efficiency were recorded with I₁ and N₁, while, the lowest values were achieved under I₆ and N₅. The opposite trend was observed with available nitrogen remained in soil after wheat harvest. This means surface irrigation and N fertigation increase the ability of wheat plants to N uptake from the soil and consequently increase yield. 4- The response of wheat grain yield to N application method under surface drip irrigation could be expressed by equations 1 and 2 as follow:-               Y_{Soil app}      =    3107.4 (N soil app.) + 56.1               (R² =  0.9973),     (1)               Y_fert          =     2756.2 (N fert.) + 31.7                      (R² = 0.9991),      (2)  While, equations 3 and 4 summarized the response of grain yield to different N treatments under sub-surface drip irrigation as follow:-              Y_fert       =    2478.1 (N fert.) - 33.298                       (R² =  0.9992),     (3)              Y_{Soil app}  =    2064.3 (N soil app.) + 70.15                 (R² = 0.9913 ),     (4)  Where: Y_{Soil app} = the estimated wheat grain yield (kg fed^-1) according to the contribution ratio of N soil application. Y_fert   = the estimated wheat grain yield (kg fed^-1) according to the contribution ratio N fertigation method. N soil app.=  N soil application ratio (%). N fert        =  N fertigation ratio (%).     From equation 1, 2, 3 and 4 it could be concluded that nitrogen fertilizer is preferable to add as soil application with surface drip irrigation, while N fertigation method has to be used with sub-surface drip irrigation.