Two field experiments were carried out at Ismailia Agricultural Research Station during 2011 and 2012 summer growing seasons to investigate the effects of applied N, P and K on peanut yield, quality and some macronutrients (N, P and K) uptake in sandy soils. Results showed that Ismailia-1 genotype surpassed Gregory genotype regarding plant growth, yield components and pod, seed quality except number of branches plant^-1 and pod yield fed.^-1 and N, P and K uptake in peanut seeds. Increasing N, P and K rates from (30-30-24 to 60-45-48kg NPK fed.^-1) significantly increased plant height, number of branches plant^-1, seed weightplant^-1, pod yield fed.^-1,100-pod weight, 100-seed weight, shelling % and N, P and K-uptake. Results also showed that the interaction among genotypes and nitrogen, phosphorus and potassium fertilization had significant effects on all studied traits in both seasons. Also pod yield (kg fed.^-1) was positively correlated with all studied characters. Generally, Ismailia-1 genotype as well as (60,45and 48 kg NPK fed.^-1) gave the highest values of most studied traits in the both seasons.