A field trial was conducted at Ismailia Research Station during the two successive summer seasons (2012 and 2013) seasons. The objective of this research was aimed to study the effect of organic matter (compost) as soil application, humic and ascorbic acids as foliar application individually in two rates 1.5 g /L and 3 g/L for each one and their combinations with compost on growth parameters, yield, its components, seed quality and quantity of sesame C.v. Sohag 1. Results indicated that foliar application of humic and ascorbic acids individually or combined with compost application markedly increased most of growth parameters, i.e., germination %, seedling vigor, plant height, fruiting zone length, No. of capsules /plant, seed weight /plant 1000-seed weight (g) and seed yield (kg/fed) compared with untreated plant. Beside of that, compost application , foliar spray with humic or ascorbic acids led to significant increase in protein %, oil %, carbohydrate %, P %, K %  and concentrations of micronutrients (Fe ,Zn ,Mn and Cu). Also, significant increase was found in protein, oil yields, P and K.  The highest values were 233.61, 635.09, 5.72 and 43.4 (kg / fed) for protein, oil yield, P and K, respectively, which achieved by using ascorbic acid only as foliar spray at (1.5 g/L). The same trend was observed in micronutrient contents and highest values were 459.66, 50.46, 321.21 and 13.83 (g/fed) for Fe, Zn, Mn and Cu, respectively. In combined treatment between compost and  humic acid at the rate (1.5 g/L) the highest values were 161.49, 473.97, 3.98 and 31.81 (Kg/fed ) for protein, oil yields, P and K contents  highest values were 379.67, 43.85, 243.31 and 9.72 (g /fed) for Fe, Zn, Mn and Cu contents.