The adsorption of Pb(ll) ions from aqueous solution by different pectin compounds was studied in a batch sorption system. In this study lead binding activity of high; low esterified pectin and pectin extracted from water hyacinth leaves as well as of kyanite was estimated under in vitro and in vivo conditions. The lead- binding capacity of all different pectin compounds was the highest within the pH range 4.0 – 8.0. The Langmuir and Freundlich sorption models were applied to describe the isotherms and sorption constants. Interactions among pectins could be well interpreted by the Langmuir model.  Obtained results indicated that pectin compounds are favorable sorbets. The largest amount of Pb(II) ions were bound by pectin with the low degree of esterification.  In experiments estimating lead removal from liver and kidney in rats preliminary given the heavy metal solution for two weeks, low esterified pectin was the most effective agents studies compared with others. They contributed to reduce lead concentration in liver and kidney as well as increased metal content in feces of laboratory animals. The results recommended that low esterified pectin can be considered as perspective compounds purposed for prevention and treatment of chronic lead poisoning.