Two field trials were carried out at the Experimental Farm, Sakha Agricultural Research Station, Kafr El-Sheikh Governorate during the two successive summer growing seasons of 2012 and 2013. The research aimed to study the effect of irrigation at different soil moisture depletion (I₁: at 45%, I₂: at 60% and I₃: at 75% depletion of available soil moisture, respectively), nitrogen rates (N₁: 60, N₂: 90 and N₃: 120 kg N fed^-1) and doses number of nitrogen application (D₁: one dose, D₂: two equal doses and D₃: three equal doses) on maize yield and its components, nitrogen uptake by plants, N-use efficiency and some water relations. The experimental design was split split plot with three replicates, the main plots were for irrigation treatments, where the sub plots were for N-rates and the sub-sub plots were for doses number of N application. The main results can be summarized as follows: Irrigation at 75 % depletion of available soil moisture (I₃) decreased seasonal water applied, water consumptive use and water stored in the effective root zone by 18.08, 16.78, and 17.02%, respectively compared with irrigation at 45% depletion. Also, the highest means of water productivity (WP) and productivity of irrigation water (PIW) were 1.95 and 1.24 kg/m³, respectively with irrigation at 60 % depletion (I₂). Irrigation at 60% depletion (I₂) recorded the highest mean of water application efficiency (89.60%), whereas the irrigation orders was I₂> I₃>I₁. Irrigation at 45% depletion (I₁) recorded the highest mean for grain yield (3.363 ton fed^-1), stalks yield (9.313 ton fed^-1), weight of 100 grains (43.899g) and ear weight (316.119g). Application of N-rate N₃ recorded the highest means of grain yield (3.507 ton fed^-1), straw yield (9.56 ton fed^-1), weight of 100 grains (43.176g) and ear weight (310.948g), respectively. Application of N-rate at three doses (D₃), recorded the highest means of grain yield (3.585 ton fed^-1), straw yield (9.216 ton fed^-1), weight of 100 grains (43.466g) and ear weight (315.202g). Irrigation at 45% depletion (I₁) recorded the highest mean of N-uptake for grains and stalks. Application of nitrogen rates increased N-uptake for maize grains and stalks up to N₃. Increased the doses number of N application increased N-uptake for maize grains and stalks up to D3 (three equal doses). The values of NUE increased by 15.65% with splitting N-rate into three doses compared with application at one dose, but decreased with increasing application N-rate and irrigation at 75 % depletion. Most of interactions among irrigation, nitrogen rates and doses number of N application showed significant effect on grain yield and its components and N-uptake in both maize grains and stalks, and positive effect on N-use efficiency