The present study is carried out under field conditions on a clay soil at the Experimental Farm of the Faculty of Agric. Mansoura Univ. during the winter season of 2012/2013 to study the combined effect of compost rice straw and bio fertilizers  in the presence of ( Indole acetic acid ,Fulvic acid ,and Gibberellic acid) as  foliar amendments on plant growth and tuber yield and quality of potato (Solanum tuberosum, L.) as well as chlorophyll content in the leaves, N, P and K concentrations in the leaves and tubers in addition to starch, Total soluble solids and nitrate content in tubers. Nine treatments were arranged in complete randomized block design with 3 replicates as follows; 1- Compost rice straw (CRS),  2- (CRS) +   Indole acetic acid (IAA), 3- CRS+ Fulvic acid (F.A) , 4- CRS + Gibberellic acid (G.A). 5- (CRS) + Mixture of Azotobacter chrococcum and Bacillus circulans (Mix), 6- (CRS) + (Mix) + (IAA), 7-(CRS) + (Mix) + (F.A), 8-(CRS) + (Mix) +    (G.A). Also, the recommended doses of N, P and K fertilizers for potato were put in consideration as a control treatment. Thus, the total numbers of treatment are 9 treatments. The obtained results can be summarized as follow: Spraying of foliar amendments either in a single form or in combination with bio fertilization led to a positive effect on the growth and yield of potato tuber. Fulvic acid were more effective for all the studied traits than other foliar amendments. The highest level of nitrate and trace elements were detected in potato tubers produced from the plants treated with the recommended of N, P and K fertilizers (control). While the lowest level produced from plants treated with fulvic acid+ the mix of bio fertilizers +CRS.  Inoculation of potato tubers with the mixture of multi strains inoculants in combination with the studied foliar amendments and CRS gave a higher magnitude of plant growth, chemical composition, yield and its components as well as quality parameters of potato tuber. The results ensure the importance of partial replacement of chemical NPK fertilizers by the use of bio and organic ones in producing potatoes. Its application would reduce the consumption of chemical fertilizers which in turn reduce the production costs as well as decrease nitrate content in the tubers besides, saving the environment from chemical pollution.