Field experiment was carried out on newly reclaimed sandy soil at Abdul- Moneam Reyad village, Bustan site during wheat growing season of 2012- 2013 to asses the response of the grain yield and biological yield of two wheat cultivars ( MISR I & MISR II) under different irrigation treatment and under different of fertilization  levels and also to determine of the main effect of studied treatmentson the some yield attributes.The obtained data revealed that, the fertilization treatments improve the productivity of the wheat crop under sprinkler irrigation system as compared with farmer's practice in sandy soil. The obtained results also  indicated that, the  fertilization  treatments significantly effect on both wheat grain yield and biological yield than the  irrigation treatments and variety of wheat crops. Also it was observed, the variety  MISR II recorded the highest grain yield (2.650 ton/fed.) and biological yield (7.595 ton fed) under irrigated treatment I₁ ( 2528 m³/fed.) and fertilization level  of 120 kg N (F₁) over studied treatments. Moreover, it can be concluded that the  wheat cultivar( MISR II) is more suitable for sandy soil than cultivar MISR I.