Two field experiments were conducted at Sids Agricultural Research Station, A.R.C., Beni Swif Governorate to study the response of soybean variety Giza.111 to rhizobium inoculation combined with bio-fertilizer under mineral fertilization of nitrogen, phosphorus and molybdenum and their interactions on growth (plant height and dry weight/plant) ,  yields (seed and straw) , nutrients concentration and uptake and protein and oil percentages and yields. Four replicates in randomized complete block design were used in both experiments with the four factors of study. Results showed that  plant height, dry weight/plant , seeds and straw yields and concentrations of nitrogen, phosphorus and molybdenum and uptake in seeds and straw as well as protein percentage and protein and oil yields were positively affected by rhizobium inoculation and 60, 13.1and 5kg/fed nitrogen , phosphorus and molybdate sodium  except N and K % in seeds and straw , P % in seeds and Mo% in straw not affected by nitrogen , bio- and molybdenum fertilization . Moreover , oil percentage in seeds did not respond to the studied factors . The dual inoculation surpassed the single inoculation . As for the interaction, the statistical analysis showed that the high level of nitrogen had a antagonistic action on the effective effect of bacterial inoculation . On the other hand , added phosphorus had a synergistic effect on enhancing the positive effects of both bacterial inoculation and molybdenum on soybean growth and yields . In general , the treatment of rhizobium +bio- inoculation + 30 + 13.1 + 5 kg/fed nitrogen , phosphorus and molybdate sodium gave the highest quality and quantity of soybean .