A field experiment was carried out at the Experimental Station, Faculty of Agriculture, CairoUniversity, Giza, Egypt, during 2013& 2014 summer seasons. The field experiment was laid out in a Randomized Complete Blok Design with three replicates. The experiment involved the following five treatments: (Control) 100% mineral-N (T₁), 100% organic as compost (6 ton fed^-1) (T₂), 75% organic (4.5 ton fed^-1) plus 25% mineral-N (T₃), 50% organic (3.0 ton fed^-1) plus 50% mineral-N (T₄) and 25% organic (1.5 ton fed^-1) plus 75 % mineral-N (T₅).This investigation was conducted to study the effect of inorganic and organic nitrogen with different combination between them on yield of sorghum and soil properties. The results showed that the bulk density and pH values in soil was reduced by increasing the organic manure rates, while total porosity was increased by addition of organic fertilizer..  Available N, P and K in soil were increased significantly by different addition rates compared with control. The available nitrogen was significant increased with T₂ treatment than other treatments. Available phosphorus and potassium in soil were significantly affected at T₃ treatmentcompared with the others treatments. Available Fe, Mn and Zn were affected by application of compost only and combined with mineral fertilizers, where the available Fe, Mn and Zn in soil increased with T₂ treatment compared with the others treatments.Thestatistical analysis revealed that T₃ treatment at first cut gave the highest values of both fresh and dry weight compared with other treatments. The results showed that nitrogen, phosphorus and potassium uptake by plants were significantly increased with T₃ treatment was the best one at the first cut.