A field experiment was conducted in the Experimental Farm of Faculty of Agric., El-Mansoura Univ. during the winter season of 2014-2015 to study the effect of mineral fertilization levels (0, 50, 75 and 100% from the recommended doses of NPK), organic manure sources (FYM, compost rice straw (CRS), compost town refuse (CTR) and chicken manure (ChK)) and enrichment organic manure as well as their interaction on yield and chemical composition of wheat plant in complete randomize block design with 3 replicates. Results indicated that; the mean values of all parameters under study fresh and dry weight, chlorophyll content, yield and yield component; weight of 100 seeds, no. of grains/spike, spike length as well as chemical composition were significantly increased as the level of NPK fertilizers was increased. The highest yield and chemical composition of wheat was realized at the rate of 100% NPK. Within the sources of organic manures studied; a superiority effect was realized for the plants treated with ChK, following with CRS, FYM and lastly CTR for increasing the average values of the previously mentioned traits as compared to the control treatment. Enrichment the sources of organic manure with the mixture of micronutrients (Zn, Fe and Mn) had a positive effect on the mean values of all the aforementioned traits. Such effect was more pronounced due to the combination between NPK levels (50 or 75% RD) and enrichment organic manure sources. The best quality and the highest mean values of growth parameters, yield and its components and chemical composition of wheat plant were realized for the plants treated with enrichment chicken manure combined with 75% NPK (RD).