Two field experiments were conducted at the Experimental Research Station in El-Serw, Agricultural Research Center during  the seasons 2012/2013 and 2013/2014 to study the effect of mineral nitrogen and organic nitrogen of compost combination treatments on grain and straw yield and N, P, K- uptake in grain and straw of some wheat varieties. The experiments were carried out in a split plot design with three replicates. Main plots were assigned to three wheat cultivars i.e., Sakha 93, Gemmiza 9 and Gemmiza 10. The sub main plots were devoted to mineral nitrogen and compost combination treatments as follows: 100 % inorganic nitrogen (90 kg fed^-1), 75 % inorganic nitrogen (67.5 kg fed^-1 ) + 25 % organic nitrogen (22.5 kg fed^-1), 50 % inorganic nitrogen (45.0 kg fed^-1 ) + 50 % organic nitrogen (45.0 kg fed^-1 ), 25 % inorganic nitrogen (22.5 kg fed^-1 ) + 75 % organic nitrogen (67.5 kg fed^-1) and 100 % organic nitrogen (90 kg fed^-1).  Obtained results showed that the greatest values of wheat grain , straw yields , N, P and K uptake in both grain and straw were those of Gemmeza 10, Gemmeza 9 and Sakha 93, respectively and 100 % inorganic nitrogen, 75 % inorganic nitrogen + 25 % organic nitrogen, 50 % inorganic nitrogen + 50 % organic nitrogen, 25 % inorganic nitrogen + 75 % organic nitrogen and 100 % organic nitrogen, respectively. 100% inorganic nitrogen for Gemmiza 10 gave the highest wheat grain and straw yields and N, P, and K uptake in grain and straw. While, applying 75% inorganic nitrogen with 25% organic nitrogen produced economic wheat grain and straw yields for Sakha 93 only. So, 25% inorganic nitrogen could be saved, and environmental pollution with mineral- N fertilizers could also be reduced. As well as improved soil properties i.e increased hydraulic conductivity,on the contrary,bulk density,Ece and pH values were decreased.