The experiments were carried in clay soil at the Experimental Farm of Faculty of Agricultural, El-Mansoura University, Egypt, to investigate the effect of foliar application with yeast and ascorbic acid on plant growth, yield and quality of eggplant (Solanum melongena L.) under different levels of NPK fertilization. Vegetative growth measurements (plant height, No. of leaves/plant, No. of branches/plant, fresh and dry weight), yield (fruits length, fruit diameter, No. of fruits and total yield), N, P, K and chlorophyll content as well as quality of fruits (C.protien, T.carbohydraties, D.faiber, V.C and V.A) were recorded to study the effects. As for, parameters of eggplant as affected by application of NPK fertilization there were a significantly increase with increasing rate of NPK from 50 up to 100% of the recommended dose then decreased with 150% NPK. The highest significant values of the aforementioned parameters were recorded with spraying plants by yeast extract (5 g/L.) comparing with the untreated plants. It could be observed that eggplants supplied with 100% NPK fertilization and foliar application of yeast gave the highest significant values of parameters under study.