During the winter season of 2013/2014, a pot trial was done at the nursery of Experimental Station Farm in Faculty of Agriculture, University of Mansoura to investigate the impact of soil types, organic fertilizers, N-levels and their interaction on growth and nutrients concentration and uptake by lettuce (Lactuca sativa L.). The trial was done in factorial trial in complete randomized block design with 3 replications. Where, the first factor integrated with the two types of soil (clay and sandy soils). The second factor incorporated with two organic fertilizers (farmyard manure "20 m³/fed" and compost "15 m³/fed"). The third factor integrated with three levels of nitrogen fertilizer (without nitrogen fertilization, 50 and 100 % of the recommended dose). The obtained results could be summarized as the following:The greatest means of height of plant, plant fresh and dry weights, N, P and K percentages and its uptake by lettuce leaves were recorded when planting seedlings of lettuce in clay soil. Lettuce plants that organic fertilizing by compost (15 m³/fed) produced the maximum values of plant height, plant fresh and dry weights, N, P and K percentages and its uptake by lettuce leaves. Increasing N- level to 60 kg N/fed (100 % of the recommended dose) gave the uppermost values of height of plant, plant fresh and dry weights, N, P and K percentages and its uptake by lettuce leaves. It can be concluded that planting lettuce seedlings in clay soil and organic fertilizing plants with compost (15 m³/fed) and 60 kg N/fed to maximizing its growth and nutrients concentration and also uptake under conditions of this study.