A field experiment was carried out at Bahtim Agricultural Research Station Farm through 2013/2014 and 2014/2015 seasons. The experimental site is located at lat. 30.80, long 31.16 and 14.00 m above the mean sea level, to study the effect of foliar spray of some antioxidants (ascorbic, citric and salicylic acids) under three nitrogen fertilizer rates (40, 60 and 80 kg N fed^-1) and their interactions on yield and its attributes as well as macronutrients uptake and protein percentage of bread wheat variety (Misr 1). The obtained results could be summarized as follows:1- Application of the highest nitrogen fertilizer rate (80 kg N fed^-1) gave a significant increase in grain weight spike^-1, spike number spike m^-2, grain number spike^-1 and 1000 grain weight (g). Also, grain, straw, biological yield and harvest index  as well as NPK uptake of wheat grain, straw, biological and protein % of grain were increased significantly when adding 80 and 60 kg N  fed^{-1 in both seasons.2-} Generally, in most cases, foliar application of any organic acids (ascorbic, citric or  salicylic) gave a significant increases in yield and its some components as well as macronutrients uptake and protein percentage of wheat in both seasons. 3- The highest significant values of some yield components, grain, straw, biological yield and harvest index as well as NPK uptake of wheat grain, straw and biological were noticed by spraying any organic acid under soil application of 60 or 80 kg N fed^{-1 in both seasons. Thus, the increases in wheat yield (quality and quantity)may be attributed to the organic acids guide to an enhancing wheat plant growth and promote its nutrients uptake as well as improving the efficiency of nitrogen fertilizer. So, under the same conditions we can reduce the recommendation of nitrogen fertilizer for wheat from 80 to 60 kg N} fed^-1 with foliar application with ascorbic, citric or salicylic acids to get the best possible wheat productivity.