A field experiment was carried out during the summer season of 2013 at the Experimental Farm, Faculty of Agriculture, Mansoura University to study the impact of spraying salicylic acid (SA) on mitigating the negative effect of drought conditions on maize hybrid plants (cross cv. Giza 10). The experiment was laid out in split plot design with three replications. In the present study, three levels (100, 75 and 50 % of water holding capacity) were arranged as main plots and two foliar applications of salicylic acid (zero "sprayed with tap water as control treatment" and 200 mg.L^-1) as sub-plots. The results showed that growth parameters, plant height (cm), fresh and dry weight of flag leaf (g), yield components (cob length (cm), no of grains/cob, 100 grains weight (g), grain yield, straw yield, cob yield ton/fed), mineral content of leaves (N, P and K in flag leaf), seed quality characteristics (crude protein, oil content and total carbohydrates %) were significantly decreased with drought stressat 50% of water holding capacity. While, the effect of salicylic acid sprayed at rate of 200 mg.L^-1 on the previously mentioned traits recorded positive impact of high water deficit as compared with the control treatment (zero mg L^-1 SA) which gave the lowest parameters. N, P and K concentrations in tested soil were significantly response (P ≤ 0.05) to drought stress, foliar spraying of (SA) and their combinations. Reduced level of water application at 50% resulted in decreases in the concentration of available N, P and K in soil. The highest concentrations of available N, P and K in soil were recorded at 75% of water holding capacity combined with 200 mg.L^-1 SA, while the lowest concentrations were recorded at 50% of water holding capacity in the absence of spraying with SA. It can be conclude that, foliar application of salicylic acid at rate of 200 mg.L^-1 could be used as appropriate growth regulator for reducing the negative effects on maize plant under water deficiency conditions.