During the winter seasons of 2015/2016 and 2016/2017, at the Experimental Farm of the Faculty of Agriculture, Mansoura University, Egypt, a pot experiment was laid out in a clayey soil, to study the effects of organic manure, chemical fertilization levels as (phosphorus and potassium) and their interactions on yield and yield component and chemical composition, of wheat (Triticum aestivum L.) plants.  Twenty seven treatments were arranged in a split-split plot design with three replicates, which were the simple combination of three treatments of organic manures (control, rice straw compost and chicken manure) as main plots, three rates of phosphorus fertilization (0, 50 and 100% of the RD.) as sub plots and three rates of potassium fertilization (0, 50 and 100% of the RD.) as sub sub plots. Thus, the total number of the experimental pots was 81 pots. The application of rice straw compost and chicken manure significantly increased the mean values of grains per spike, spike length (cm), weight of 1000 grains, as well as grain and straw yields (g pot^-1) of wheat plants as compared with the control treatment. On other words; rice straw compost was the most effective treatment in improving quantitative yield and nutrient concentrations. Application of phosphorus fertilization significantly increased all parameters under study for the plants treated with both rates over that obtained from the untreated plants. In this respect; the highest values were realized from the treatment of 100% P-fertilization.Adding potassium fertilization at 100% of the recommended dose to wheat plants achieved the highest values for all traits as compared to the untreated plants.The obtained  results revealed that  the integrated treatment of rice straw compost + 100% P and K fertilizations  produced the highest values of yield and its components of wheat plants  throughout all growth stages  during both seasons. N, P and K concentrations in the dry matter of wheat plants were also improved due.